5-HT₃ Receptor

5-HT₃ Receptor Related Products (29):

By Type:	Pan (1) Selective (9)
By Effects:	Inhibitors (7) Agonists (8) Antagonists (10)

Cat. No.	Product Name	Effect	Purity

HY-15414

Vortioxetine	Inhibitor	98.61%
Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial agonist of 5-HT_1B (K_i: 15 nM, 33 nM).

HY-14564A

GTS-21 dihydrochloride	Antagonist	99.65%
GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti inflammatory and cognition enhancing activities. GTS-21 dihydrochloride is also a α4β2 (K_i=20 nM for humanα4β2) and 5-HT3A receptor (IC₅₀=3.1 μM) antagonist.

HY-15414A

Vortioxetine hydrobromide	Inhibitor	99.87%
Vortioxetine (Lu AA 21004) hydrobromide is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM).

HY-100938

m-CPBG hydrochloride	Agonist	99.85%
m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT₃ agonist. m-CPBG hydrochloride can be used for the research of neurological disease.

HY-B0750

Dolasetron		99.90%
Dolasetron (MDL-73147) is a serotonin 5-HT3 receptor antagonist. Dolasetron acts as an antiemetics agent and can be used for the research of chemotherapy-induced nausea and vomiting in cancer.

HY-WAA0304

Agmatine
1-(4-Aminobutyl) guanidine (Agmatine) is an orally active analgesic that can cross the blood-brain barrier. 1-(4-Aminobutyl) guanidine targets the 5-HT_2A receptor, 5-HT₃ receptor, α₂-adrenergic receptor, and I1 imidazoline receptor. 1-(4-Aminobutyl) guanidine produces dose-dependent analgesic effects in various pain models. 1-(4-Aminobutyl) guanidine can be used in research related to visceral pain, neuropathic pain, and inflammatory pain.

HY-121001

Amanozine	Agonist
Amanozine (Compound 15) is a 5-HT₃ serotonin receptor agonist. Amanozine is promising for research of nervous system disorders.

HY-182701

5-HT3 antagonist-7	Antagonist
5-HT3 antagonist-7 (Compound 7e) is a competitive and selective 5-HT₃ receptor antagonist. 5-HT3 antagonist-7 inhibits 5-HT-induced contractions in guinea pig ileum and guinea pig thoracic aorta. 5-HT3 antagonist-7 prevents 2-methyl-5-HT-induced vomiting episodes in ferrets.

HY-75813

2-Aminonicotinaldehyde		99.98%
2-Aminonicotinaldehyde is a synthetic intermediate. 2-Aminonicotinaldehyde can be used for the synthesis of 5-HT3 receptor antagonists, AKT inhibitors, and other compounds. 2-Aminonicotinaldehyde is applicable to research on depression and cancers (including hepatocellular carcinoma).

HY-103118

PU02	Antagonist	99.76%
PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT₃ receptor, with IC₅₀ values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT₃A and 5-HT₃AB receptors respectively.

HY-101046

Quipazine dimaleate	Agonist	99.96%
Quipazine dimaleate is a 5-HT agonist with a K_i value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC₅₀ of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research.

HY-15414R

Vortioxetine (Standard)	Inhibitor
Vortioxetine (Standard) is an analytical standard for Vortioxetine. This product is intended for research and analytical applications. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM).

HY-101709

Ricasetron	Antagonist	98.62%
Ricasetron (BRL-46470) is a selective and orally active 5-HT3 receptor antagonist. Ricasetron displays little or no affinity for a variety of other neurotransmitter receptors. Ricasetron has anxiolytic and antiemetic effects.

HY-100552

VUF10166	Antagonist	99.83%
VUF10166 is a potent and high-affinity 5-HT₃ receptor antagonist, with K_i values of 0.04 nM (5-HT₃A) and 22 nM (5-HT₃AB). VUF10166 inhibits 5-HT-induced responses at 5-HT₃A and 5-HT₃AB receptors at nanomolar concentrations. At 5-HT₃ receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC₅₀ of 5.2 μM.

HY-15414AS

Vortioxetine-d₈ hydrobromide	Inhibitor	99.41%
Vortioxetine-d₈ (Lu AA 21004-d₈) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM).

HY-105449A

KB R6933	Antagonist
KB R6933 (KB 6806 maleate) is a potent, selective and orally active 5-HT3 receptor antagonist. KB R6933 can inhibit the diarrhea induced by 5-HT (HY-B1473A), but not that by Castor Oil (HY-107799) or prostaglandin E2 (PGE2) (HY-101952). KB R6933 can inhibit 5-HT-induced bradycardia.

HY-15414S

Vortioxetine-d₈	Inhibitor
Vortioxetine-d₈ (Lu AA 21004-d₈) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM).

HY-181351

PSN09	Agonist
PSN09 is a blood-brain barrier-permeable agonist of PSAM⁴-GlyR and PSAM⁴-5-HT₃ receptors with high affinity. 18F-labeled PSN09 serves as a radiotracer for PET imaging in non-human primates.

HY-120810

MCI-225 hydrate hydrochloride	Antagonist
MCI-225 (DDP-225) hydrate hydrochloride is a selective and orally active noradrenaline (NA) reuptake inhibitor with 5-HT3 receptor antagonism. MCI-225 hydrate hydrochloride has antidepressant-like and anxiolytic-like properties. MCI-225 hydrate hydrochloride can be used for the study of anxiety disorder.

HY-183136

Batanopride	Antagonist
Batanopride (BMY 25801) is a selective 5-HT₃ receptor antagonist. Batanopride inhibits chemotherapy-induced emesis, and prevents Cisplatin (HY-17394)-, Cyclophosphamide (HY-17420)-, Doxorubicin (HY-15142A)-, and total body irradiation-induced emesis.

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